Abstract
A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Calotropis / chemistry*
-
Cell Line, Tumor
-
Drug Screening Assays, Antitumor
-
Humans
-
Magnetic Resonance Spectroscopy
-
Pregnanolone / analogs & derivatives*
-
Pregnanolone / chemistry
-
Pregnanolone / isolation & purification
-
Pregnanolone / pharmacology
-
Spectrometry, Mass, Fast Atom Bombardment
-
Spectrophotometry, Infrared
Substances
-
Antineoplastic Agents, Phytogenic
-
calotropone
-
Pregnanolone