Abstract
A line probe assay (INNO-LiPA DR, version 3) for the detection of hepatitis B virus mutations that confer resistance to entecavir therapy was evaluated. The INNO-LiPA DR assay is a highly sensitive assay that is easily applicable for the detection and monitoring of entecavir resistance-conferring mutations and is more sensitive than sequencing for the detection of mixed sequences.
Publication types
-
Evaluation Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antiviral Agents / pharmacology*
-
DNA, Viral / genetics
-
Genotype
-
Guanine / analogs & derivatives*
-
Guanine / pharmacology
-
Hepatitis B virus / drug effects
-
Hepatitis B virus / genetics*
-
Hepatitis B virus / isolation & purification*
-
Humans
-
Molecular Diagnostic Techniques / methods*
-
Mutation, Missense
-
Nucleic Acid Hybridization / methods*
-
Sensitivity and Specificity
Substances
-
Antiviral Agents
-
DNA, Viral
-
entecavir
-
Guanine