Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects

Antimicrob Agents Chemother. 2009 Feb;53(2):828-31. doi: 10.1128/AAC.00927-08. Epub 2008 Dec 1.

Abstract

The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antimalarials / analysis
  • Antimalarials / pharmacokinetics*
  • Area Under Curve
  • Artemisinins / analysis
  • Artemisinins / pharmacokinetics*
  • Chemistry, Pharmaceutical
  • Chromatography, Liquid
  • Cross-Over Studies
  • Drug Combinations
  • Half-Life
  • Humans
  • Male
  • Quinolines / analysis
  • Quinolines / pharmacokinetics*
  • Tandem Mass Spectrometry
  • Therapeutic Equivalency

Substances

  • Antimalarials
  • Artemisinins
  • Drug Combinations
  • Quinolines
  • artenimol
  • piperaquine