Abstract
The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.
Publication types
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antimalarials / analysis
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Antimalarials / pharmacokinetics*
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Area Under Curve
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Artemisinins / analysis
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Artemisinins / pharmacokinetics*
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Chemistry, Pharmaceutical
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Chromatography, Liquid
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Cross-Over Studies
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Drug Combinations
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Half-Life
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Humans
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Male
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Quinolines / analysis
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Quinolines / pharmacokinetics*
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Tandem Mass Spectrometry
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Therapeutic Equivalency
Substances
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Antimalarials
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Artemisinins
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Drug Combinations
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Quinolines
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artenimol
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piperaquine