NO-producing activity of macrophages infected with tick-borne encephalitis virus

N G Plekhova; L M Somova; D V Zavorueva; N V Krylova; G N Leonova

doi:10.1007/s10517-008-0087-5

NO-producing activity of macrophages infected with tick-borne encephalitis virus

Bull Exp Biol Med. 2008 Mar;145(3):344-7. doi: 10.1007/s10517-008-0087-5.

Authors

N G Plekhova¹, L M Somova, D V Zavorueva, N V Krylova, G N Leonova

Affiliation

¹ Institute of Epidemiology and Microbiology, Siberian Division of Russian Academy of Medical Sciences, Vladivostok. pl_nat@hotmail.com

PMID: 19039940
DOI: 10.1007/s10517-008-0087-5

Abstract

Stimulation of NO-producing activity of macrophages infected with tick-borne encephalitis virus was demonstrated. Activity of NADPH-diaphorase, inducible NO synthase, and cytochrome oxidase, a heme-containing mitochondrial enzyme reflecting NO production by the nitrite reductase pathway was observed against the background of production of NO metabolites by cells.

MeSH terms

Animals
Cells, Cultured
Electron Transport Complex IV / metabolism
Encephalitis Viruses, Tick-Borne*
Macrophages / metabolism*
Macrophages / virology*
Mice
NADPH Dehydrogenase / metabolism
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase Type II / metabolism

Substances

Nitric Oxide
Nitric Oxide Synthase Type II
Nos2 protein, mouse
NADPH Dehydrogenase
Electron Transport Complex IV