Modulation of apoptosis of mononuclear cells under conditions of oxidative stress

V V Novitsky; N V Ryazantseva; N Y Chasovskih; E G Starikova; E V Kaygorodova; Y V Starikov; O B Jukova

doi:10.1007/s10517-008-0071-0

Modulation of apoptosis of mononuclear cells under conditions of oxidative stress

Bull Exp Biol Med. 2008 Mar;145(3):283-6. doi: 10.1007/s10517-008-0071-0.

Authors

V V Novitsky¹, N V Ryazantseva, N Y Chasovskih, E G Starikova, E V Kaygorodova, Y V Starikov, O B Jukova

Affiliation

¹ Department of Pathophysiology, Department of Fundamentals of Clinical Medicine, Siberian State Medical University, Federal Agency for Health Care and Social Development, Tomsk.

PMID: 19039924
DOI: 10.1007/s10517-008-0071-0

Abstract

We studied mitochondrial and type 1 tumor necrosis factor-a receptor (TNFR1)-mediated pathways triggering the apoptotic program in mononuclear cells under conditions of oxidative stress. Intensification of intracellular production of reactive oxygen forms is accompanied by an increase in the number of annexin-positive TNFRI-presenting cells and mononuclear cells with reduced mitochondrial transmembrane potential in case of induction of oxidative stress with 1 mM H2O2 in vitro and in patients with pneumonia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / physiology*
Humans
Leukocytes, Mononuclear / cytology*
Leukocytes, Mononuclear / physiology
Membrane Potentials
Oxidative Stress / physiology*
Pneumonia / blood
Reactive Oxygen Species / blood
Receptors, Tumor Necrosis Factor, Type I / physiology*

Substances

Reactive Oxygen Species
Receptors, Tumor Necrosis Factor, Type I