Asymmetric sulfur ylide based enantioselective synthesis of D-erythro-sphingosine

Org Biomol Chem. 2008 Dec 21;6(24):4502-4. doi: 10.1039/b814882a. Epub 2008 Oct 17.

Abstract

An asymmetric sulfur ylide reaction was employed to prepare an epoxide intermediate in a convergent manner. This epoxide was efficiently transformed into D-erythro-sphingosine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Sphingosine / analogs & derivatives*
  • Sphingosine / chemical synthesis
  • Sphingosine / chemistry
  • Stereoisomerism
  • Substrate Specificity

Substances

  • erythro-(2R,3S)-sphingosine
  • Sphingosine