New housing areas are a ubiquitous feature of modern life in the developing and developed world alike built in response to rising social, demographic and economic pressures. Inevitably, these new developments will have an impact on the environment around them. Empirical evidence confirms the close relationship between urbanisation and ambient water quality. However, what is lacking so far is a detailed and more generalised analysis of environmental impact at a relatively small scale. The aim of this paper is to quantify the impact of new developments on river water quality within an integrated system modelling perspective. To conduct the impact analyses, an existing integrated urban wastewater model was used to predict water flow and quality in the sewer system, treatment plant and receiving water body. The impact on combined sewer overflow (CSO) discharges, treatment plant effluent, and within the river at various reaches is analysed by 'locating' a new development on a semi-hypothetical urban catchment. River water quality is used as feedback to constrain the scale of the new development within different thresholds in compliance with water quality standards. Further, the regional sensitivity analysis (RSA) method is applied to reveal the parameters with the greatest impact on water quality. These analyses will help to inform town planners and water specialists who advise them, how to minimise the impact of such developments given the specific context.