Alkaloids from roots of Stemona sessilifolia and their antitussive activities

Planta Med. 2009 Feb;75(2):174-7. doi: 10.1055/s-0028-1088345. Epub 2008 Nov 24.

Abstract

Protostemonamide ( 1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine ( 2), stemospironine ( 4), and maistemonine ( 7), showed significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration; stemonamine ( 11) had antitussive activity following i. c. v. administration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / isolation & purification
  • 4-Butyrolactone / therapeutic use
  • Alkaloids / chemistry
  • Alkaloids / isolation & purification
  • Alkaloids / therapeutic use*
  • Animals
  • Antitussive Agents / chemistry
  • Antitussive Agents / isolation & purification
  • Antitussive Agents / therapeutic use*
  • Azepines / chemistry
  • Azepines / isolation & purification
  • Azepines / therapeutic use*
  • Citric Acid
  • Cough / chemically induced
  • Cough / drug therapy*
  • Disease Models, Animal
  • Guinea Pigs
  • Molecular Structure
  • Phytotherapy*
  • Plant Extracts
  • Plant Roots
  • Stemonaceae / chemistry*

Substances

  • Alkaloids
  • Antitussive Agents
  • Azepines
  • Plant Extracts
  • protostemonamide
  • Citric Acid
  • 4-Butyrolactone