Abstract
Protostemonamide ( 1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine ( 2), stemospironine ( 4), and maistemonine ( 7), showed significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration; stemonamine ( 11) had antitussive activity following i. c. v. administration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / chemistry
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / therapeutic use
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / therapeutic use*
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Animals
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Antitussive Agents / chemistry
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Antitussive Agents / isolation & purification
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Antitussive Agents / therapeutic use*
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Azepines / chemistry
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Azepines / isolation & purification
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Azepines / therapeutic use*
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Citric Acid
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Cough / chemically induced
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Cough / drug therapy*
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Disease Models, Animal
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Guinea Pigs
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Molecular Structure
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Phytotherapy*
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Plant Extracts
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Plant Roots
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Stemonaceae / chemistry*
Substances
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Alkaloids
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Antitussive Agents
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Azepines
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Plant Extracts
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protostemonamide
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Citric Acid
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4-Butyrolactone