Chaetoglobins A and B, two unusual alkaloids from endophytic Chaetomium globosum culture

Hui Ming Ge; Wei Yun Zhang; Gang Ding; Patchareenart Saparpakorn; Yong Chun Song; Supa Hannongbua; Ren Xiang Tan

doi:10.1039/b812144c

Chaetoglobins A and B, two unusual alkaloids from endophytic Chaetomium globosum culture

Chem Commun (Camb). 2008 Dec 7:(45):5978-80. doi: 10.1039/b812144c. Epub 2008 Oct 10.

Authors

Hui Ming Ge¹, Wei Yun Zhang, Gang Ding, Patchareenart Saparpakorn, Yong Chun Song, Supa Hannongbua, Ren Xiang Tan

Affiliation

¹ Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, PR China.

PMID: 19030558
DOI: 10.1039/b812144c

Abstract

Chaetoglobins A (1) and B (2), two azaphilone alkaloid dimers with an unprecedented skeleton, were characterized from an endophytic fungus Chaetomium globosum with the former ascertained to be a significant cytotoxin valuable for anti-tumor drug discovery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification
Alkaloids / pharmacology
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Benzopyrans / chemistry
Benzopyrans / isolation & purification
Benzopyrans / pharmacology
Chaetomium / chemistry*
Drug Screening Assays, Antitumor
Isoquinolines / chemistry*
Isoquinolines / pharmacology
Molecular Structure
Pigments, Biological / chemistry
Pigments, Biological / isolation & purification
Pigments, Biological / pharmacology
Tumor Cells, Cultured

Substances

Alkaloids
Antineoplastic Agents
Benzopyrans
Isoquinolines
Pigments, Biological
azaphilone
chaetoglobin A
chaetoglobin B