Abstract
The crystal structures of co-crystals of two systems of chiral carboxylic acids, optically active and racemic 2-phenylpropionic acid and 2-phenylbutyric acid, with isonicotinamide are reported to investigate the effects of the chirality of the chiral carboxylic acids on the melting point of the co-crystal complexes. It was found that the racemic co-crystal has a higher melting point than the optically active co-crystal, which correlates with the denser packing arrangement inherent in centrosymmetric space groups.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Calorimetry, Differential Scanning
-
Crystallization
-
Crystallography, X-Ray
-
Models, Molecular
-
Molecular Conformation
-
Niacinamide / chemical synthesis
-
Niacinamide / chemistry*
-
Phenylbutyrates / chemical synthesis
-
Phenylbutyrates / chemistry*
-
Phenylpropionates / chemical synthesis
-
Phenylpropionates / chemistry*
-
Stereoisomerism
-
Transition Temperature*
Substances
-
Phenylbutyrates
-
Phenylpropionates
-
Niacinamide
-
isonicotinamide
-
hydratropic acid
-
2-phenylbutyric acid