Real-time monitoring of blood using coherent anti-Stokes Raman spectroscopy

Arthur Dogariu; Alexander Goltsov; Marlan O Scully

doi:10.1117/1.2978064

Real-time monitoring of blood using coherent anti-Stokes Raman spectroscopy

J Biomed Opt. 2008 Sep-Oct;13(5):054004. doi: 10.1117/1.2978064.

Authors

Arthur Dogariu¹, Alexander Goltsov, Marlan O Scully

Affiliation

¹ Princeton University, Applied Physics Group, Princeton, New Jersey 08544, USA. adogariu@princeton.edu

PMID: 19021384
DOI: 10.1117/1.2978064

Abstract

We demonstrate a real-time method of measuring the vibrational Raman spectrum of whole blood. Using a novel coherent Raman technique, we record the vibrational spectrum of the red blood cells from picoliters in blood in milliseconds. This method will allow real-time in vivo blood monitoring.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Blood Chemical Analysis / instrumentation*
Blood Chemical Analysis / methods
Computer Systems
Equipment Design
Equipment Failure Analysis
Reproducibility of Results
Sensitivity and Specificity
Spectrum Analysis, Raman / instrumentation*
Spectrum Analysis, Raman / methods
Tomography, Optical Coherence / instrumentation*