Single-nucleotide polymorphisms in Rv2629 are specific for Mycobacterium tuberculosis genotypes Beijing and Ghana but not associated with rifampin resistance

Susanne Homolka; Claudio Köser; John Archer; Sabine Rüsch-Gerdes; Stefan Niemann

doi:10.1128/JCM.01237-08

Single-nucleotide polymorphisms in Rv2629 are specific for Mycobacterium tuberculosis genotypes Beijing and Ghana but not associated with rifampin resistance

J Clin Microbiol. 2009 Jan;47(1):223-6. doi: 10.1128/JCM.01237-08. Epub 2008 Nov 19.

Authors

Susanne Homolka¹, Claudio Köser, John Archer, Sabine Rüsch-Gerdes, Stefan Niemann

Affiliation

¹ Forschungszentrum Borstel, National Reference Center for Mycobacteria, Research Center Borstel, Parkallee 1, Borstel, Germany.

Abstract

Sequence analysis of 58 multidrug-resistant Mycobacterium tuberculosis complex strains from Germany and 55 susceptible strains from a reference collection comprising major phylogenetic lineages confirmed that variations in Rv2629, 191A/C and 965C/T, are specific for genotypes Beijing and Ghana, respectively, but not involved in the development of rifampin (rifampicin) resistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / pharmacology*
Bacterial Proteins / genetics*
DNA, Bacterial / genetics*
Drug Resistance, Bacterial*
Genotype
Germany
Humans
Mycobacterium tuberculosis / classification*
Mycobacterium tuberculosis / genetics*
Polymorphism, Single Nucleotide*
Rifampin / pharmacology*

Substances

Antitubercular Agents
Bacterial Proteins
DNA, Bacterial
Rv2629 protein, Mycobacterium
Rifampin