Helicobacter pylori virulence and the diversity of gastric cancer in Asia

Lam Tung Nguyen; Tomohisa Uchida; Kazunari Murakami; Toshio Fujioka; Masatsugu Moriyama

doi:10.1099/jmm.0.2008/003160-0

Helicobacter pylori virulence and the diversity of gastric cancer in Asia

J Med Microbiol. 2008 Dec;57(Pt 12):1445-1453. doi: 10.1099/jmm.0.2008/003160-0.

Authors

Lam Tung Nguyen^{1

2}, Tomohisa Uchida^{3

2}, Kazunari Murakami¹, Toshio Fujioka¹, Masatsugu Moriyama²

Affiliations

¹ Department of Gastroenterology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
² Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
³ Department of Human Environmental and Social Medicine, Faculty of Medicine, Oita University, Oita 879-5593, Japan.

PMID: 19018013
DOI: 10.1099/jmm.0.2008/003160-0

Abstract

Infection with cagPAI positive strains of Helicobacter pylori is recognized as being associated with an increased risk of gastric cancer. This article reviews the current knowledge on the structures and pathological functions of cagPAI and the CagA protein, focusing especially on the molecular mechanism through which CagA may be involved in gastric carcinogenesis. The possible link between the geographical distribution of cagPAI and cagA variations and gastric cancer diversity in Asia is also discussed.

Publication types

Review

MeSH terms

Antigens, Bacterial / genetics
Asia / epidemiology
Bacterial Proteins / genetics
Female
Genomic Islands / genetics
Helicobacter Infections / complications*
Helicobacter Infections / epidemiology*
Helicobacter Infections / microbiology
Helicobacter pylori / genetics
Helicobacter pylori / pathogenicity*
Humans
Male
Stomach Neoplasms / epidemiology*
Stomach Neoplasms / microbiology
Stomach Neoplasms / pathology
Virulence

Substances

Antigens, Bacterial
Bacterial Proteins
cagA protein, Helicobacter pylori