Comparison of the performances of two in-house rapid methods for antitubercular drug susceptibility testing

Antimicrob Agents Chemother. 2009 Feb;53(2):808-10. doi: 10.1128/AAC.00960-08. Epub 2008 Nov 17.

Abstract

Resistance to rifampin (rifampicin), isoniazid, and streptomycin of 69 Mycobacterium tuberculosis isolates was analyzed by an in-house method based on mycobacteriophage D29 and a colorimetric micromethod. Both methods showed sensitivity and specificity values ranging from 93% to 100%. These simple methods offer an option for drug resistance assessment of M. tuberculosis.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / pharmacology*
  • Colorimetry
  • Microbial Sensitivity Tests / economics
  • Microbial Sensitivity Tests / methods*
  • Mycobacteriophages / drug effects
  • Mycobacterium tuberculosis / drug effects*
  • Reference Standards
  • Reproducibility of Results

Substances

  • Antitubercular Agents