Nanoparticle-induced surface reconstruction of phospholipid membranes

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18171-5. doi: 10.1073/pnas.0807296105. Epub 2008 Nov 14.

Abstract

The nonspecific adsorption of charged nanoparticles onto single-component phospholipid bilayers bearing phosphocholine headgroups is shown, from fluorescence and calorimetry experiments, to cause surface reconstruction at the points where nanoparticles adsorb. Nanoparticles of negative charge induce local gelation in otherwise fluid bilayers; nanoparticles of positive charge induce otherwise gelled membranes to fluidize locally. Through this mechanism, the phase state deviates from the nominal phase transition temperature by tens of degrees. This work generalizes the notions of environmentally induced surface reconstruction, prominent in metals and semiconductors. Bearing in mind that chemical composition in these single-component lipid bilayers is the same everywhere, this offers a mechanism to generate patchy functional properties in phospholipid membranes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adsorption
  • Fluorescence
  • Lipid Bilayers*
  • Microscopy, Electron
  • Nanoparticles*
  • Phospholipids / chemistry*
  • Surface Properties

Substances

  • Lipid Bilayers
  • Phospholipids