Autoinducer-2 production in Campylobacter jejuni contributes to chicken colonization

Appl Environ Microbiol. 2009 Jan;75(1):281-5. doi: 10.1128/AEM.01803-08. Epub 2008 Nov 14.

Abstract

Inactivation of luxS, encoding an AI-2 biosynthesis enzyme, in Campylobacter jejuni strain 81-176 significantly reduced colonization of the chick lower gastrointestinal tract, chemotaxis toward organic acids, and in vitro adherence to LMH chicken hepatoma cells. Thus, AI-2 production in C. jejuni contributes to host colonization and interactions with epithelial cells.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Bacterial Adhesion
  • Bacterial Proteins / genetics
  • Campylobacter Infections / microbiology*
  • Campylobacter jejuni / genetics
  • Campylobacter jejuni / pathogenicity*
  • Campylobacter jejuni / physiology
  • Carbon-Sulfur Lyases / genetics
  • Chemotaxis
  • Chickens
  • Gene Deletion
  • Hepatocytes / microbiology
  • Homoserine / analogs & derivatives*
  • Homoserine / metabolism
  • Intestine, Small / microbiology*
  • Lactones / metabolism*
  • Virulence Factors / metabolism*

Substances

  • Bacterial Proteins
  • Lactones
  • N-octanoylhomoserine lactone
  • Virulence Factors
  • Homoserine
  • Carbon-Sulfur Lyases
  • LuxS protein, Bacteria