Abstract
Inactivation of luxS, encoding an AI-2 biosynthesis enzyme, in Campylobacter jejuni strain 81-176 significantly reduced colonization of the chick lower gastrointestinal tract, chemotaxis toward organic acids, and in vitro adherence to LMH chicken hepatoma cells. Thus, AI-2 production in C. jejuni contributes to host colonization and interactions with epithelial cells.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Animals, Newborn
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Bacterial Adhesion
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Bacterial Proteins / genetics
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Campylobacter Infections / microbiology*
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Campylobacter jejuni / genetics
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Campylobacter jejuni / pathogenicity*
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Campylobacter jejuni / physiology
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Carbon-Sulfur Lyases / genetics
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Chemotaxis
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Chickens
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Gene Deletion
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Hepatocytes / microbiology
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Homoserine / analogs & derivatives*
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Homoserine / metabolism
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Intestine, Small / microbiology*
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Lactones / metabolism*
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Virulence Factors / metabolism*
Substances
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Bacterial Proteins
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Lactones
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N-octanoylhomoserine lactone
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Virulence Factors
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Homoserine
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Carbon-Sulfur Lyases
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LuxS protein, Bacteria