Abstract
Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Animals
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans / physiology
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Caloric Restriction
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Diet*
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Dietary Supplements
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Drosophila melanogaster / metabolism
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Drosophila melanogaster / physiology
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Enzyme Activation / drug effects
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Flavonoids / pharmacology
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Histone Deacetylases / metabolism
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Humans
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Phenols / pharmacology
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Polyphenols
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae / physiology
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Sirtuins / metabolism*
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Vertebrates / metabolism
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Vertebrates / physiology
Substances
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Flavonoids
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Phenols
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Polyphenols
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Sirtuins
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Histone Deacetylases