Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior

Ilona Papp; Jens Dernedde; Sven Enders; Rainer Haag

doi:10.1039/b813414f

Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior

Chem Commun (Camb). 2008 Nov 30:(44):5851-3. doi: 10.1039/b813414f. Epub 2008 Oct 3.

Authors

Ilona Papp¹, Jens Dernedde, Sven Enders, Rainer Haag

Affiliation

¹ Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, 14195, Berlin, Germany.

PMID: 19009103
DOI: 10.1039/b813414f

Abstract

Hyperbranched polyglycerols (HPGs) are ideal scaffolds for the multivalent presentation of saccharides, due to their biocompatible, carbohydrate-like properties; here, we report the conjugation of galactosesugar moieties to HPG, and the multivalent effect of these constructs on selectin binding.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemical synthesis*
Biocompatible Materials / chemistry
E-Selectin / metabolism
Galactose / chemistry*
Glycerol / chemistry*
L-Selectin / metabolism
P-Selectin / antagonists & inhibitors
P-Selectin / metabolism
Polymers / chemistry*
Protein Binding
Selectins / metabolism*

Substances

Biocompatible Materials
E-Selectin
P-Selectin
Polymers
Selectins
L-Selectin
polyglycerol
Glycerol
Galactose