The vasovagal tonus index as a prognostic indicator in dogs with dilated cardiomyopathy

J Small Anim Pract. 2008 Nov;49(11):587-92. doi: 10.1111/j.1748-5827.2008.00654.x.

Abstract

Objectives: To investigate the prognostic and diagnostic value of heart rate variability (HRV) using the vasovagal tonus index (VVTI) in dogs suffering from idiopathic dilated cardiomyopathy (DCM).

Methods: Electrocardiographic (ECG) recordings of 369 patients presented to a referral centre between 1993 and 2006 were reviewed.

Results: VVTI values were calculated from 132 dogs. Lower VVTI values were found in patients in International Small Animal Cardiac Health Council (ISACHC) heart failure (HF) class 2 and 3 compared with class 1. VVTI was found to be positively correlated with survival time (ST) in class 2 and 3 patients. When a cut-off value of 7.59 for VVTI was used, the test could differentiate patients in ISACHC HF class 1 versus 2 and 3 with a sensitivity of 89 per cent and a specificity of 62.5 per cent. The ST for patients with VVTI values less than 7.59 was significantly lower.

Clinical significance: The VVTI is a useful index, obtained from a standard ECG recording that estimates HRV in dogs and does not require any specific equipment for its calculation. It can be useful as a diagnostic tool to assess the severity of HF and is a useful prognostic tool in dogs with DCM.

Publication types

  • Validation Study

MeSH terms

  • Animals
  • Cardiomyopathy, Dilated / diagnosis
  • Cardiomyopathy, Dilated / mortality
  • Cardiomyopathy, Dilated / physiopathology
  • Cardiomyopathy, Dilated / veterinary*
  • Dog Diseases / diagnosis*
  • Dog Diseases / mortality
  • Dog Diseases / physiopathology*
  • Dogs
  • Electrocardiography / veterinary
  • Female
  • Heart Rate*
  • Linear Models
  • Male
  • Predictive Value of Tests
  • Prognosis
  • ROC Curve
  • Retrospective Studies
  • Severity of Illness Index*
  • Survival Analysis