An initial case of suppressed restenosis with nuclear factor-kappa B decoy transfection after percutaneous coronary intervention

J Gene Med. 2009 Jan;11(1):89-91. doi: 10.1002/jgm.1266.

Abstract

Background: Nuclear factor-kappa B (NF-kappaB) is well known for playing a pivotal role in restenosis after percutaneous coronary intervention (PCI).

Methods and results: This is the first report to demonstrate an effect of NF-kappaB decoy oligodeoxynucleotides (ODN) to prevent restenosis after PCI after a 4-year observation using a coronary computed tomography (CT) scan. We showed that the decoy treatment suppressed neointimal formation after stent implantation compared to that in the same artery.

Conclusion: Thus, for the first time, we demonstrate the clinical usefulness of the CT scan to reveal the effects of NF-kappaB decoy ODN transfer after PCI.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Coronary Restenosis / drug therapy
  • Coronary Restenosis / prevention & control*
  • Humans
  • Male
  • Middle Aged
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / genetics
  • NF-kappa B / therapeutic use
  • Oligodeoxyribonucleotides / administration & dosage
  • Oligodeoxyribonucleotides / chemistry
  • Oligodeoxyribonucleotides / therapeutic use
  • Stents
  • Transfection

Substances

  • NF-kappa B
  • Oligodeoxyribonucleotides