Abstract
From a study on the biological activity of fungal stemphones and their derivatives, five derivatives having an O-alkyl moiety at C-11 of stemphone C were found to inhibit lipid droplet accumulation in macrophages without any cytotoxic effect. Among the derivatives, those having O-isopropyl and O-isobutyl were the most potent inhibitors by blocking the synthesis of both cholesteryl ester (CE) and triacylglycerol (TG), the main constituents of lipid droplets in macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Atherosclerosis / metabolism
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Atherosclerosis / prevention & control
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Benzoquinones / pharmacology*
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Cholesterol / metabolism
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Cholesterol Esters / biosynthesis
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Diacylglycerol O-Acyltransferase / antagonists & inhibitors
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Diacylglycerol O-Acyltransferase / metabolism
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Foam Cells / drug effects
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Foam Cells / metabolism*
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Lipid Metabolism / drug effects*
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Macrophages, Peritoneal / drug effects
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Macrophages, Peritoneal / metabolism
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Mice
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Sterol O-Acyltransferase / antagonists & inhibitors
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Sterol O-Acyltransferase / metabolism
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Triglycerides / biosynthesis
Substances
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Benzoquinones
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Cholesterol Esters
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Triglycerides
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stemphone
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Cholesterol
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DGAT2 protein, mouse
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Diacylglycerol O-Acyltransferase
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Sterol O-Acyltransferase
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sterol O-acyltransferase 1