Abstract
The synthesis of 3,6-bicyclolides from erythromycin A oxime is described. This novel class of bridged bicyclic macrolides demonstrates potent in vitro and in vivo activities against a broad spectrum of bacteria including resistant respiratory tract pathogens.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry*
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Chemistry, Pharmaceutical / methods*
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Crystallography, X-Ray / methods
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Drug Design*
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Drug Resistance, Multiple
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Humans
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Macrolides / chemical synthesis*
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Macrolides / chemistry*
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Macrolides / classification*
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Mice
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Microbial Sensitivity Tests
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Models, Chemical
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Molecular Conformation
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Respiratory System / microbiology
Substances
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Anti-Bacterial Agents
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Macrolides