Abstract
A new method for the construction of pyrophosphates is reported based on the coupling of a sugar phosphate and a nucleoside phosphoramidite. The in situ formed phosphate-phosphite intermediate was subsequently oxidized with tBuOOH. Three UDP-N-acetylglucosamine derivatives were prepared using this one-pot procedure in good yields.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetylglucosamine / chemistry
-
Carbohydrates / chemistry*
-
Chemistry, Organic / methods
-
Magnetic Resonance Spectroscopy / methods
-
Models, Chemical
-
Nucleosides / chemistry
-
Nucleotides / chemistry
-
Organophosphorus Compounds / chemistry*
-
Phosphates / chemistry
-
Phosphites / chemistry
-
Uridine Diphosphate / chemistry
Substances
-
Carbohydrates
-
Nucleosides
-
Nucleotides
-
Organophosphorus Compounds
-
Phosphates
-
Phosphites
-
phosphoramidite
-
Uridine Diphosphate
-
Acetylglucosamine