Abstract
Two general synthetic methods are described, by which the highly fluorescent and photostable BODIPY group can be inserted in and aligned with the alkyl backbone of linear lipids. These methods have been used to prepare strongly emitting analogues of the leishmanicidal drug miltefosine, in which the antiparasite activity in vitro of the original drug is preserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemical synthesis*
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Antiprotozoal Agents / pharmacology
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Boron Compounds / chemical synthesis*
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Boron Compounds / pharmacology
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Chemistry, Pharmaceutical / methods*
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Drug Design
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / pharmacology
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Humans
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Leishmania donovani / metabolism*
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Lipids / chemistry
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Models, Chemical
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Phosphorylcholine / analogs & derivatives*
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Phosphorylcholine / chemistry*
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Phosphorylcholine / pharmacology
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Solvents / chemistry
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Spectrophotometry / methods
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Antiprotozoal Agents
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Boron Compounds
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Fluorescent Dyes
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Lipids
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Solvents
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Phosphorylcholine
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miltefosine