Ascomycones A-C, heptaketide metabolites from an unidentified ascomycete

J Nat Prod. 2008 Nov;71(11):1973-6. doi: 10.1021/np800570w. Epub 2008 Nov 6.

Abstract

The ascomycones A-C (1-3), three novel heptaketide-derived secondary metabolites, have been isolated from cultures of an unknown ascomycete. While 1 and 2 are closely related pyranonaphthoquinones, 3 has a bicyclic dihydronaphthoquinone core. Compounds 2 and 3 exhibited significant activity against several phytopathogenic fungi.

MeSH terms

  • Animals
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Ascomycota / chemistry*
  • Caenorhabditis elegans / drug effects
  • Enterobacter / drug effects
  • Escherichia coli / drug effects
  • French Guiana
  • Humans
  • Lepidium sativum / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Naphthoquinones / chemistry
  • Naphthoquinones / isolation & purification*
  • Naphthoquinones / pharmacology
  • Plant Bark / microbiology
  • Proteus vulgaris / drug effects
  • Pyrans / chemistry
  • Pyrans / isolation & purification*
  • Pyrans / pharmacology
  • Setaria Plant / drug effects
  • Tylenchoidea / drug effects

Substances

  • Antifungal Agents
  • Naphthoquinones
  • Pyrans
  • ascomycone A
  • ascomycone B
  • ascomycone C