Abstract
The ascomycones A-C (1-3), three novel heptaketide-derived secondary metabolites, have been isolated from cultures of an unknown ascomycete. While 1 and 2 are closely related pyranonaphthoquinones, 3 has a bicyclic dihydronaphthoquinone core. Compounds 2 and 3 exhibited significant activity against several phytopathogenic fungi.
MeSH terms
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Ascomycota / chemistry*
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Caenorhabditis elegans / drug effects
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Enterobacter / drug effects
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Escherichia coli / drug effects
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French Guiana
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Humans
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Lepidium sativum / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Naphthoquinones / chemistry
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Naphthoquinones / isolation & purification*
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Naphthoquinones / pharmacology
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Plant Bark / microbiology
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Proteus vulgaris / drug effects
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Pyrans / chemistry
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Pyrans / isolation & purification*
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Pyrans / pharmacology
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Setaria Plant / drug effects
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Tylenchoidea / drug effects
Substances
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Antifungal Agents
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Naphthoquinones
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Pyrans
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ascomycone A
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ascomycone B
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ascomycone C