The association between family, school and subjective health was examined in a large representative sample of Greek children and adolescents (N = 3034). We hypothesized that (a) family and school factors are associated with health, even after controlling for gender and economic status; (b) family and school factors are directly related to satisfaction with life and health complaints, but indirectly to self-rated health. According to the findings, family and school factors were related to subjective health, even though this relation was weakening with age. Family and school factors were associated with self-rated health through health complaints and life satisfaction.