Zn(II) ions bind very efficiently to tandem repeat region of "prion related protein" (PrP-rel-2) of zebra-fish. MS and potentiometric evidence

Dalton Trans. 2008 Nov 28:(44):6117-20. doi: 10.1039/b811224j. Epub 2008 Sep 23.

Abstract

Multi-histidine peptide fragments of zebra-fish prion protein are effective ligands for Zn(II) ions. Moreover the formation of a dinuclear complex species with a longer peptide can suggest the existence of the cooperative effect in the metal ion binding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cations, Divalent / metabolism
  • Potentiometry
  • Prions / metabolism*
  • Spectrometry, Mass, Electrospray Ionization
  • Tandem Repeat Sequences*
  • Zebrafish / metabolism
  • Zinc / metabolism*

Substances

  • Cations, Divalent
  • Prions
  • Zinc