We report on a 5-year-old boy with hyperzincemia and hypercalprotectinemia. Treatment began with Tacrolimus at the age of 4 years and 6 months. Despite an initial correction of clinical and biological symptoms, zincemia and calprotectinemia progressively worsened with secondary reappearance of symptoms.
Conclusion: Tacrolimus seems to have a transient effect in the treatment of Hyperzincemia and hyperprolactinemia.