Bone mineral density, vascular calcifications, and arterial stiffness in peritoneal dialysis patients

Perit Dial Int. 2008 Nov-Dec;28(6):668-72.

Abstract

The objective of this study was to evaluate the correlation of bone mineral density (BMD), evaluated by DXA, with vascular calcifications, arterial stiffness, and vascular disease in patients on peritoneal dialysis. Vascular calcifications were evaluated by vascular calcification score on plain x ray, and arterial stiffness was measured by pulse wave velocity using the Complior device (Artech Medical, Pantin, France). Adjusting for multiple factors, lower BMD at the femoral neck, but not at the lumbar spine, was associated with higher pulse wave velocity (p = 0.037), higher vascular calcification score (p = 0.013), and peripheral artery disease (p = 0.006). These data reinforce the hypothesis of the existence of a link between bone disease and cardiovascular disease in dialysis patients.

MeSH terms

  • Adult
  • Blood Vessels / pathology*
  • Bone Density*
  • Calcinosis
  • Comorbidity
  • Cross-Sectional Studies
  • Diabetic Nephropathies / epidemiology
  • Diabetic Nephropathies / pathology
  • Diabetic Nephropathies / physiopathology
  • Elasticity
  • Female
  • Femur Neck / physiopathology
  • Humans
  • Kidney Failure, Chronic / epidemiology
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Peripheral Vascular Diseases / epidemiology
  • Peripheral Vascular Diseases / pathology
  • Peritoneal Dialysis*