Phylogenetics and pathogenesis of early avian influenza viruses (H5N1), Nigeria

Emerg Infect Dis. 2008 Nov;14(11):1753-5. doi: 10.3201/eid1411.080557.

Abstract

Three highly pathogenic avian influenza subtype H5N1 and 4 Newcastle disease viruses were isolated from sick or dead chickens in southwestern Nigeria. Sequencing and phylogenetic analysis placed them within H5N1 subclade 2.2.2. Intravenous and intranasal pathogenicity tests produced systemic disease with vascular endothelial cell tropism in chickens.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Brain / pathology
  • Chickens / virology
  • Endothelium, Vascular / virology
  • Inflammation / pathology
  • Influenza A Virus, H5N1 Subtype / classification*
  • Influenza A Virus, H5N1 Subtype / isolation & purification
  • Influenza A Virus, H5N1 Subtype / pathogenicity*
  • Influenza in Birds / epidemiology*
  • Influenza in Birds / pathology
  • Influenza in Birds / virology*
  • Lung / pathology
  • Myocardium / pathology
  • Necrosis
  • Nigeria / epidemiology
  • Phylogeny
  • Virulence