"Pure by NMR"?

Timothy D W Claridge; Stephen G Davies; Mario E C Polywka; Paul M Roberts; Angela J Russell; Edward D Savory; Andrew D Smith

doi:10.1021/ol802211p

"Pure by NMR"?

Org Lett. 2008 Dec 4;10(23):5433-6. doi: 10.1021/ol802211p.

Authors

Timothy D W Claridge¹, Stephen G Davies, Mario E C Polywka, Paul M Roberts, Angela J Russell, Edward D Savory, Andrew D Smith

Affiliation

¹ Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

PMID: 18975956
DOI: 10.1021/ol802211p

Abstract

Integration of a (13)C-(1)H satellite peak of a given (12)C-(1)H parent resonance within a quantitative (1)H NMR spectrum and comparison to the minor component represents a simple protocol for the accurate determination of diastereoisomeric ratios of up to 1000:1 (i.e., 99.8% de).