Phosphate diester and DNA hydrolysis by a multivalent, nanoparticle-based catalyst

J Am Chem Soc. 2008 Nov 26;130(47):15744-5. doi: 10.1021/ja801794t.

Abstract

2-nm gold nanoclusters coated with Zn(II) complexes bearing auxiliary hydrogen bond donors act as multivalent catalysts capable of promoting the hydrolysis of model phosphate diesters with exceptional activity and inducing DNA double strand cleavage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • DNA / chemistry*
  • Esters / chemistry*
  • Hydrolysis
  • Ligands
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Phosphates / chemistry*
  • Plasmids / chemistry

Substances

  • Esters
  • Ligands
  • Phosphates
  • DNA