Abstract
Two new dimeric proanthocyanidins, ephedrannin B ( 2) and mahuannin E ( 4), along with two known congeners, ephedrannin A ( 1) and mahuannin D ( 3), were isolated from the roots of Ephedra sinica Stapf. Based on NMR, MS, and CD analysis, the structures of the new compounds were deduced to be 5,7,4'-trihydroxyflavan-[4(alpha)-->8,2(alpha)-->O-->7]-kaempferol ( 2) and 5,7,4'-trihydroxyflavan-[4(beta)-->8,2(beta)-->O-->7]- EPI-afzelechin ( 4). The compounds 1 - 4 were evaluated for cytotoxicity against three tumor cell lines (SGC-7901, HepG2, and HeLa), and 2 was found to be significantly active.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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Cytotoxins / isolation & purification
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Cytotoxins / pharmacology*
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Drug Screening Assays, Antitumor
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Ephedra sinica / chemistry*
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Humans
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Magnetic Resonance Spectroscopy
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Roots / chemistry
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Proanthocyanidins / isolation & purification
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Proanthocyanidins / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Cytotoxins
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Plant Extracts
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Proanthocyanidins
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ephedrannin B