Antimicrobial activity of ethylenediaminedisuccinate metal complexes

Natália J S Costa; Cíntia R Bombardieri; Juliana S Kuribayashi; Maristela M de Camargo; Leandro H Andrade; Edna Kagohara; Breno P Espósito

doi:10.1002/cbdv.200890196

Antimicrobial activity of ethylenediaminedisuccinate metal complexes

Chem Biodivers. 2008 Oct;5(10):2156-2159. doi: 10.1002/cbdv.200890196.

Authors

Natália J S Costa¹, Cíntia R Bombardieri², Juliana S Kuribayashi², Maristela M de Camargo², Leandro H Andrade¹, Edna Kagohara¹, Breno P Espósito¹

Affiliations

¹ University of São Paulo, Institute of Chemistry, Av. Lineu Prestes 748 sala 1265, 05508-000, São Paulo, Brazil (phone: +55-11-3091-2181; fax: +55-11-3815-5579).
² University of São Paulo, Institute of Biomedical Sciences, Av. Lineu Prestes 2415, 05508-000, São Paulo, Brazil.

PMID: 18972505
DOI: 10.1002/cbdv.200890196

Abstract

It is shown that metal complexes of the biodegradable ligand ethylenediaminedisuccinic acid (edds) present antimicrobial activity towards fungi and bacteria. [Cd(edds)], in particular, is more toxic than free Cd2+ to Aspergillus niger, behaving as a 'Trojan Horse' in the facilitated delivery of the toxic metal into the fungus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology*
Aspergillus niger / drug effects
Cell Cycle / drug effects
Cell Line
Ethylenediamines / chemistry*
Humans
Metals, Heavy / chemistry*
Metals, Heavy / pharmacology
Organometallic Compounds / chemistry
Organometallic Compounds / pharmacology*
Pycnoporus / drug effects
Staphylococcus aureus / drug effects
Structure-Activity Relationship
Succinates / chemistry*

Substances

Anti-Infective Agents
Ethylenediamines
Metals, Heavy
Organometallic Compounds
Succinates
N,N'-ethylenediamine disuccinic acid