On-line sample treatment and FT-IR determination of doxylamine succinate in pharmaceuticals

Josep F Ventura-Gayete; Miguel de la Guardia; Salvador Garrigues

doi:10.1016/j.talanta.2006.02.023

On-line sample treatment and FT-IR determination of doxylamine succinate in pharmaceuticals

Talanta. 2006 Dec 15;70(5):1100-6. doi: 10.1016/j.talanta.2006.02.023. Epub 2006 Mar 20.

Authors

Josep F Ventura-Gayete¹, Miguel de la Guardia, Salvador Garrigues

Affiliation

¹ Department of Analytical Chemistry, Research Building, University of Valencia, 50 Dr. Moliner St., 46100 Burjassot, Valencia, Spain.

PMID: 18970887
DOI: 10.1016/j.talanta.2006.02.023

Abstract

A low solvent consumption method for Fourier transform infrared spectroscopy (FT-IR) determination of doxylamine succinate in pharmaceuticals has been developed. The analyte was continuous and selectively extracted with a 13% (v/v) ethanol:chloroform solvent mixture, recirculating the solvent through the sample and monitoring the process by FT-IR. Doxylamine succinate was determined by on-line standard addition measuring the peak area in the regions 1730-1710 and 1485-1462cm(-1) corrected with a two-point baseline established between 2000 and 1800cm(-1). This new method implies low volumes of chloroformic solvent mixture, only 2.6mL per sample, in front of classical batch FT-IR methods, improving analytical efficiency and reducing waste generation. The on-line extraction and standard addition determination of doxylamine succinate allowed a throughput of 10h(-1).