Square wave adsorptive stripping voltammetric determination of famotidine in urine

Sławomira Skrzypek; Witold Ciesielski; Adam Sokołowski; Selahattin Yilmaz; Dorota Kaźmierczak

doi:10.1016/j.talanta.2005.01.017

Square wave adsorptive stripping voltammetric determination of famotidine in urine

Talanta. 2005 Jun 15;66(5):1146-51. doi: 10.1016/j.talanta.2005.01.017.

Authors

Sławomira Skrzypek¹, Witold Ciesielski, Adam Sokołowski, Selahattin Yilmaz, Dorota Kaźmierczak

Affiliation

¹ Department of Instrumental Analysis, University of Łódź, Pomorska 163, 90236 Łódź, Poland.

PMID: 18970102
DOI: 10.1016/j.talanta.2005.01.017

Abstract

Electrochemical studies of famotidine were carried out using voltammetric techniques: cyclic voltammetry, linear sweep and square wave adsorptive stripping voltammetry. The dependence of the current on pH, buffer concentration, nature of the buffer, and scan rate was investigated. The best results for the determination of famotidine were obtained in MOPS buffer solution at pH 6.7. This electroanalytical procedure enabled to determine famotidine in the concentration range 1x10(-9)-4x10(-8)molL(-1) by linear sweep adsorptive stripping voltammetry (LS AdSV) and 5x10(-10)-6x10(-8)molL(-1) by square wave adsorptive stripping voltammetry (SW AdSV). Repeatability, precision and accuracy of the developed methods were checked. The detection and quantification limits were found to be 1.8x10(-10) and 6.2x10(-10)molL(-1) for LS AdSV and 4.9x10(-11) and 1.6x10(-10)molL(-1) for SW AdSV, respectively. The method was applied for the determination of famotidine in urine.