Coordination properties of cefadroxil antibiotic: synthesis and equilibrium studies of the binary and ternary complexes involving amino acids and DNA units

M M Shoukry; W M Hosny; A A Razik; R A Mohamed

doi:10.1016/s0039-9140(97)00089-1

Coordination properties of cefadroxil antibiotic: synthesis and equilibrium studies of the binary and ternary complexes involving amino acids and DNA units

Talanta. 1997 Nov;44(11):2109-19. doi: 10.1016/s0039-9140(97)00089-1.

Authors

M M Shoukry¹, W M Hosny, A A Razik, R A Mohamed

Affiliation

¹ Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

PMID: 18966960
DOI: 10.1016/s0039-9140(97)00089-1

Abstract

The formation equilibria for the binary complexes of Cu(II), Ni(II), Co(II), Zn(II), Mn(II), Hg(II), Cd(II), Ca(II), and Mg(II) with cefadroxil (Cef) and for the ternary complexes Cu(Cef)(L), where L refers to amino acid or DNA, were investigated. The protonation constants of cefadroxil and formation constants of the formed complexes were determined at 25 degrees C and mu = 0.1 M NaNo(3). Cooper(II) and cobalt(II) complexes of cefadroxil were isolated in solid state and characterized by elemental analysis, infrared and electronic spectral, conductivity and magnetic measurement.