Stem cells have different needs for REST

PLoS Biol. 2008 Oct 28;6(10):e271. doi: 10.1371/journal.pbio.0060271.

Abstract

REST is a well known repressor of neuronal gene expression. Genome-wide analysis of REST occupancy in different cell types now reveals new and cell-specific roles for REST in embryonic stem cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism*
  • Gene Expression Regulation, Developmental
  • Humans
  • Models, Biological
  • Neurons / cytology
  • Neurons / metabolism
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • Repressor Proteins / physiology*
  • Stem Cells / cytology
  • Stem Cells / metabolism*

Substances

  • RE1-silencing transcription factor
  • Repressor Proteins