Abstract
Early diagnosis of Alzheimer's disease remains a tactful poser. In order to clarify the importance of beta amyloid protein dosage (Abeta1-42) and protein tau (t-tau) in such pathology, we have rigorously studied three well recruited populations that match in age: healthy controls (n = 32), Alzheimer patients (n = 87) and non Alzheimer dementia (n = 31) patients. The combination of Abeta1-42 and t-tau at baseline yielded a sensitivity of 85.29 % for detection of Alzheimer's disease and the specificity was by 96.77 % to differentiate controls. So the combination of these tow markers helps in the diagnosis of Alzheimer because of the high specificity and sensibility of this method.
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / cerebrospinal fluid*
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Alzheimer Disease / diagnosis*
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Amyloid beta-Peptides / cerebrospinal fluid*
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Biomarkers
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Data Interpretation, Statistical
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Dementia / cerebrospinal fluid
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Dementia / diagnosis
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Dementia, Vascular / cerebrospinal fluid
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Dementia, Vascular / diagnosis
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Diagnosis, Differential
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Diagnostic and Statistical Manual of Mental Disorders
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Female
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Humans
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Lewy Body Disease / cerebrospinal fluid
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Lewy Body Disease / diagnosis
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Neuropsychological Tests
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Parkinson Disease / cerebrospinal fluid
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Parkinson Disease / diagnosis
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Peptide Fragments / cerebrospinal fluid*
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Psychiatric Status Rating Scales
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Sensitivity and Specificity
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Statistics, Nonparametric
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tau Proteins / cerebrospinal fluid*
Substances
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Amyloid beta-Peptides
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Biomarkers
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Peptide Fragments
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amyloid beta-protein (1-42)
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tau Proteins