MITAgating viral infection

Immunity. 2008 Oct 17;29(4):513-5. doi: 10.1016/j.immuni.2008.09.010.

Abstract

Two recent papers, one in this issue of Immunity (Zhong et al., 2008), report the identification of a membrane protein, termed MITA or STING, that activates the transcription factor IRF3 to induce type-I interferons to mitigate viral infection.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Interferon Regulatory Factor-3 / metabolism
  • Interferon Type I / immunology
  • Interferon Type I / metabolism*
  • Membrane Proteins / metabolism*
  • Mice
  • Protein Kinases / metabolism
  • Protein Structure, Tertiary
  • RNA Helicases / metabolism*
  • RNA, Viral / immunology
  • RNA, Viral / metabolism*
  • Signal Transduction
  • Toll-Like Receptors / immunology
  • Toll-Like Receptors / metabolism*
  • Virus Diseases / immunology*
  • Virus Diseases / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Interferon Regulatory Factor-3
  • Interferon Type I
  • Membrane Proteins
  • RNA, Viral
  • Toll-Like Receptors
  • Protein Kinases
  • RNA Helicases