Abstract
Nortriterpenoids, sphenadilactone C (1) and sphenasin A (2), together with four known lignans (3-6), were isolated from the leaves and stems of Schisandra sphenanthera. Their structures were elucidated by extensive analysis of 1D and 2D NMR spectroscopic data and compound 2 was further confirmed by single-crystal X-ray diffraction. Compound 1 features a partial enol moiety and an acetamide group in its structure. In addition, compounds 1, 3-6 showed weak anti-HIV-1 activity with EC(50) values in the range of 15.5-29.5 microg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line
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Cyclooctanes / chemistry
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Cyclooctanes / isolation & purification
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Cyclooctanes / pharmacology
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Dioxoles / chemistry
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Dioxoles / isolation & purification
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Dioxoles / pharmacology
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HIV-1 / drug effects
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HeLa Cells
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Humans
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Lignans / chemistry*
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Lignans / isolation & purification
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Lignans / pharmacology
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Microbial Sensitivity Tests
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Polycyclic Compounds / chemistry
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Polycyclic Compounds / isolation & purification
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Polycyclic Compounds / pharmacology
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Schisandra / chemistry*
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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Cyclooctanes
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Dioxoles
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Lignans
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Plant Extracts
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Polycyclic Compounds
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Triterpenes
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sphenadilactone C
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sphenasin A
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schisantherin D
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schizandrer A
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schizandrin
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gomisin J