Steroids linked with amide bond-extended cholesterol

Steroids. 2009 Jan;74(1):88-94. doi: 10.1016/j.steroids.2008.09.010. Epub 2008 Oct 2.

Abstract

New type of linear cholesterol-like molecules based on cholesterol extended by attachment of etienic acid derivatives was designed and oligosteroids with two to four units were synthesized. Amide bond was used for inter steroid connections and 1-hydroxybenzotriazole active ester method was adapted for their formations. Use of disteroids as larger building blocks was applied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Androstenes / chemistry*
  • Cholesterol / chemical synthesis*
  • Cholesterol / chemistry*
  • Molecular Structure

Substances

  • Amides
  • Androstenes
  • etienic acid
  • Cholesterol