Current state for the development of metallopharmaceutics and anti-diabetic metal complexes

Chem Soc Rev. 2008 Nov;37(11):2383-92. doi: 10.1039/b710347f. Epub 2008 Sep 26.

Abstract

This tutorial review introduces the current state of metallopharmaceutics development by focusing on the topics of anti-diabetic vanadium and zinc complexes. Over thousands of years, people have produced many types of inorganic compounds, and the modern concept of chemotherapy was achieved by Ehrlich, who used an arsenic-containing compound to treat syphilis. Since then, many metallopharmaceutics have been developed worldwide. This review will be helpful to researchers who are interested in the current states of not only metallopharmaceutics but also anti-diabetic metal complexes.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arsphenamine / chemistry
  • Cisplatin / chemistry
  • History, 16th Century
  • History, 19th Century
  • History, 20th Century
  • History, Ancient
  • Humans
  • Hypoglycemic Agents* / chemistry
  • Hypoglycemic Agents* / history
  • Hypoglycemic Agents* / metabolism
  • Hypoglycemic Agents* / pharmacology
  • Metals* / chemistry
  • Metals* / metabolism
  • Metals* / pharmacology
  • Pharmaceutical Preparations* / chemistry
  • Pharmaceutical Preparations* / history
  • Pharmaceutical Preparations* / metabolism
  • Vanadium / metabolism
  • Vanadium / pharmacology
  • Vanadium / toxicity
  • Zinc Compounds / metabolism
  • Zinc Compounds / toxicity

Substances

  • Hypoglycemic Agents
  • Metals
  • Pharmaceutical Preparations
  • Zinc Compounds
  • Vanadium
  • Arsphenamine
  • Cisplatin