The use of chemical double-mutant cycles in biomolecular recognition studies: application to HCV NS3 protease inhibitors

ChemMedChem. 2008 Nov;3(11):1654-7. doi: 10.1002/cmdc.200800214.
No abstract available

MeSH terms

  • Antiviral Agents / pharmacology*
  • Catalytic Domain
  • Chemistry, Pharmaceutical / methods
  • Drug Design
  • Gene Deletion
  • Glycine / chemistry
  • Hepacivirus / metabolism*
  • Inhibitory Concentration 50
  • Molecular Conformation
  • Mutation*
  • Peptides / chemistry
  • Protein Structure, Tertiary
  • Structure-Activity Relationship
  • Thermodynamics
  • Viral Nonstructural Proteins / genetics*
  • Viral Nonstructural Proteins / metabolism*

Substances

  • Antiviral Agents
  • NS3 protein, hepatitis C virus
  • Peptides
  • Viral Nonstructural Proteins
  • Glycine