Evolving genetic code

Proc Jpn Acad Ser B Phys Biol Sci. 2008;84(2):58-74. doi: 10.2183/pjab.84.58.

Abstract

In 1985, we reported that a bacterium, Mycoplasma capricolum, used a deviant genetic code, namely UGA, a "universal" stop codon, was read as tryptophan. This finding, together with the deviant nuclear genetic codes in not a few organisms and a number of mitochondria, shows that the genetic code is not universal, and is in a state of evolution. To account for the changes in codon meanings, we proposed the codon capture theory stating that all the code changes are non-disruptive without accompanied changes of amino acid sequences of proteins. Supporting evidence for the theory is presented in this review. A possible evolutionary process from the ancient to the present-day genetic code is also discussed.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Codon
  • Evolution, Molecular*
  • Genes, Bacterial
  • Genetic Code*
  • Mycoplasma capricolum / genetics
  • RNA, Messenger / genetics

Substances

  • Codon
  • RNA, Messenger