Myeloproliferative disorder by TKO

Cell Stem Cell. 2008 Oct 9;3(4):361-2. doi: 10.1016/j.stem.2008.09.008.

Abstract

In this issue of Cell Stem Cell, Viatour et al. (2008) delete all three members of the retinoblastoma tumor suppressor gene family in hematopoietic stem cells, resulting in a myeloproliferative disorder. The disease was cell autonomous and resulted from alterations in the primitive hematopoietic cells.

Publication types

  • Comment
  • Introductory Journal Article

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism
  • Cell Differentiation*
  • Cell Lineage*
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / metabolism*
  • Mice
  • Mice, Knockout
  • Myeloproliferative Disorders / etiology
  • Oligonucleotide Array Sequence Analysis
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / metabolism*
  • Retinoblastoma-Like Protein p107 / genetics
  • Retinoblastoma-Like Protein p107 / metabolism*
  • Retinoblastoma-Like Protein p130 / genetics
  • Retinoblastoma-Like Protein p130 / metabolism*
  • Signal Transduction

Substances

  • Cell Cycle Proteins
  • Retinoblastoma Protein
  • Retinoblastoma-Like Protein p107
  • Retinoblastoma-Like Protein p130