Abstract
In this issue of Cell Stem Cell, Viatour et al. (2008) delete all three members of the retinoblastoma tumor suppressor gene family in hematopoietic stem cells, resulting in a myeloproliferative disorder. The disease was cell autonomous and resulted from alterations in the primitive hematopoietic cells.
Publication types
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Comment
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Introductory Journal Article
MeSH terms
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Animals
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Cell Cycle Proteins / metabolism
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Cell Differentiation*
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Cell Lineage*
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / metabolism*
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Mice
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Mice, Knockout
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Myeloproliferative Disorders / etiology
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Oligonucleotide Array Sequence Analysis
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Retinoblastoma Protein / genetics
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Retinoblastoma Protein / metabolism*
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Retinoblastoma-Like Protein p107 / genetics
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Retinoblastoma-Like Protein p107 / metabolism*
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Retinoblastoma-Like Protein p130 / genetics
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Retinoblastoma-Like Protein p130 / metabolism*
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Signal Transduction
Substances
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Cell Cycle Proteins
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Retinoblastoma Protein
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Retinoblastoma-Like Protein p107
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Retinoblastoma-Like Protein p130