The frenzied rhythm of our times leads our patients not only to resource to diet integrators-remorselessly overcoming difficulties or prejudices-to fulfill increasingly frequent nutritional needs due to decreasingly "correct" eating habits, but also to fight against a myriad of skin conditions. The rationale of a combined approach for the antiaging treatment of skin is based on the synergic effect between functional substances applied locally, where the problem arises, and other agents working from the inside to correct a need, to restore altered functions or conditions and to guarantee the correct intake of nutrients or active substances. This work discusses the active ingredients mostly used in the oral treatment of skin aging, together with the scientific evidences that do or do not support their use.