Synthesis of biindolyls via palladium-catalyzed reactions

J Org Chem. 2008 Nov 21;73(22):9177-80. doi: 10.1021/jo801846b. Epub 2008 Oct 22.

Abstract

An unprecedented synthesis of a range of high value homo- and heterobiindolyls is presented. The one-pot Miyaura borylation and subsequent Suzuki-Miyaura coupling sequence allows for the construction of the highly sterically congested C-C bond between two bromoindoles in modest to good overall yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boronic Acids / chemistry
  • Catalysis
  • Indicators and Reagents / chemistry
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Ligands
  • Palladium / chemistry*
  • Solvents / chemistry

Substances

  • Boronic Acids
  • Indicators and Reagents
  • Indoles
  • Ligands
  • Solvents
  • Palladium