Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates

Eleni K Efthimiadou; Maria E Katsarou; Michael Fardis; Christos Zikos; Emmanuel N Pitsinos; Athanasios Kazantzis; Leondios Leondiadis; Marina Sagnou; Dionisios Vourloumis

doi:10.1016/j.bmcl.2008.10.027

Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6058-61. doi: 10.1016/j.bmcl.2008.10.027. Epub 2008 Oct 11.

Authors

Eleni K Efthimiadou¹, Maria E Katsarou, Michael Fardis, Christos Zikos, Emmanuel N Pitsinos, Athanasios Kazantzis, Leondios Leondiadis, Marina Sagnou, Dionisios Vourloumis

Affiliation

¹ Chemical Biology Program, Institute of Physical Chemistry, NCSR 'DEMOKRITOS', PO Box 60228, GR-153 10 Aghia, Paraskevi, Greece.

PMID: 18938075
DOI: 10.1016/j.bmcl.2008.10.027

Abstract

Several novel gadolinium chelates conjugated with paclitaxel, colchicine and thyroxine have been prepared as MRI contrast agents targeted to tubulin and thyroxine-binding globulin, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Colchicine / chemistry
Contrast Media / chemical synthesis*
Contrast Media / chemistry
Female
Gadolinium / chemistry*
HeLa Cells
Humans
Magnetic Resonance Imaging
Molecular Structure
Organometallic Compounds / chemical synthesis*
Organometallic Compounds / chemistry
Paclitaxel / chemistry
Thyroxine / chemistry
Thyroxine-Binding Proteins / drug effects*
Tubulin / drug effects*

Substances

Contrast Media
Organometallic Compounds
Thyroxine-Binding Proteins
Tubulin
Gadolinium
Paclitaxel
Thyroxine
Colchicine