Abstract
3-Alkylpyridine alkaloids are very common secondary metabolites from marine sponges of the order Haplosclerida. Here, we report on the identification and synthesis of the first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources. Due to the lack of a pure sample of the new compound, structure elucidation had to rely on HPLC and MS(n).
MeSH terms
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Alkaloids / chemistry*
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Animals
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Cell Line
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Cell Proliferation / drug effects
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Escherichia coli / drug effects
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Haliclona / chemistry*
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Mice
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Pyridinium Compounds / analysis
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Pyridinium Compounds / chemical synthesis*
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Pyridinium Compounds / pharmacology*
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Pyridinium Compounds / toxicity
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Staphylococcus aureus / drug effects
Substances
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Alkaloids
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Pyridinium Compounds